Absence of deleterious effect on long-term kidney graft survival of rejection episodes with complete functional recovery

被引:64
作者
Vereerstraeten, P
Abramowicz, D
dePauw, L
Kinnaert, P
机构
[1] Dept. Nephrology, Dialysis, T., CUB Hôpital Erasme, Université Libre De Bruxelles, Brussels
[2] Dept. Nephrologie, Dialyse T., CUB Hôpital Erasme, 070 Brussels, Route de Lennik
关键词
D O I
10.1097/00007890-199706270-00006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Rejection episodes (RE) exert a detrimental influence on long-term kidney graft outcome. However, the impact of the severity of those RE on graft survival and the factors that could predict this impact are ill defined, The present retrospective study was undertaken on adult patients who received 582 cadaver kidney transplants at our center during the last 12 years, to assess the impact on graft survival of RE occurring during the first year after transplantation and to uncover the factors associated with the severity of those RE. Methods. Three grades of rejection were defined: (1) rejection without loss of graft function (benign rejection); (2) rejection followed by partial loss of graft function (severe rejection); and (3) rejection with return to dialysis (irreversible rejection), The grafts were distributed among four groups: (1) grafts free of rejection; (2) grafts with benign RE (only grade 1 RE); (3) grafts with severe RE (one or more grade 2 RE); and (4) grafts with irreversible (grade 3) RE. Results. Multivariate analyses revealed that (1) the occurrence of RE during the first posttransplant year (group 1 versus groups 2, 3, and 4) was significantly associated with primary immunosuppression with CsA rather than with OKT3 monoclonal antibody, the number of HLA-B + DR mismatches, and the younger recipient's age; (2) in patients with rejection, OKT3 monoclonal antibody prophylaxis was less often used in patients with irreversible RE (group 4) than in those with reversible RE (group 2, benign, and group 3, severe); and (3) no single factor was able to differentiate patients with benign RE (group 2) from those with severe RE (group 3), For grafts still functioning 1 year after transplantation, long-term graft survival was similar in grafts with either no RE or benign RE, but it was significantly lower (P < 0.0001) in grafts with severe RE: 8-year survival rates were 89% and 60%, respectively, The decline in graft survival after 1 year was significantly correlated with the serum creatinine value but not with the dose of cyclosporine at 1 year. Conclusions. Benign RE occurring during the first year after transplantation and resulting in no loss of graft function do not exert a detrimental influence on long-term kidney graft outcome. In contrast, the prognosis of grafts with severe RE during the same period of time is much poorer.
引用
收藏
页码:1739 / 1743
页数:5
相关论文
共 18 条
[1]   THE LONG-TERM EFFECTS OF PROPHYLACTIC OKT3 MONOCLONAL-ANTIBODY IN CADAVER KIDNEY-TRANSPLANTATION - A SINGLE-CENTER, PROSPECTIVE, RANDOMIZED STUDY [J].
ABRAMOWICZ, D ;
GOLDMAN, M ;
DEPAUW, L ;
VANHERWEGHEM, JL ;
KINNAERT, P ;
VEREERSTRAETEN, P .
TRANSPLANTATION, 1992, 54 (03) :433-437
[2]   RISK-FACTORS FOR CHRONIC REJECTION IN RENAL-ALLOGRAFT RECIPIENTS [J].
ALMOND, PS ;
MATAS, A ;
GILLINGHAM, K ;
DUNN, DL ;
PAYNE, WD ;
GORES, P ;
GRUESSNER, R ;
NAJARIAN, JS ;
FERGUSON ;
PAUL ;
SCHAFFER .
TRANSPLANTATION, 1993, 55 (04) :752-757
[3]   EARLY VERSUS LATE ACUTE RENAL-ALLOGRAFT REJECTION - IMPACT ON CHRONIC REJECTION [J].
BASADONNA, GP ;
MATAS, AJ ;
GILLINGHAM, KJ ;
PAYNE, WD ;
DUNN, DL ;
SUTHERLAND, DER ;
GORES, PF ;
GRUESSNER, RWG ;
NAJARIAN, JS .
TRANSPLANTATION, 1993, 55 (05) :993-995
[4]  
Bishop M.M., 1975, DISCRETE MULTIVARIAT
[5]  
BRENNER BM, 1982, NEW ENGL J MED, V307, P652, DOI 10.1056/NEJM198209093071104
[6]  
Cecka J M, 1989, Clin Transpl, P425
[7]  
CECKA JM, 1991, TRANSPL P, V23, P1963
[8]  
Concepts Abacus, 1994, SURV TOOLS STAT VIEW
[9]  
FERGUSON R, 1994, CLIN TRANSPLANT, V8, P328
[10]  
GEHAN EA, 1965, BIOMETRIKA, V52, P203, DOI 10.1093/biomet/52.1-2.203