The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases

被引:114
作者
Catty, P [1 ]
dExaerde, AD [1 ]
Goffeau, A [1 ]
机构
[1] UNIV CATHOLIQUE LOUVAIN,UNITE BIOCHIM PHYSIOL,B-1348 LOUVAIN,BELGIUM
关键词
D O I
10.1016/S0014-5793(97)00446-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
A total of sixteen open reading frames encoding for P-type ATPases have been identified in the complete genome sequence of Saccharomyces cerevisiae. Phylogenetic analysis distinguishes 6 distinct families, Topology predictions, identification of aminoacid sequence motifs and phenotype analysis of the available mutants suggest that these families correspond to ATPases transporting either H+ (2 members), Ca2+ (2 members), Na+ (3 members), heavy metals (2 members), possibly aminophospholipids (5 members including 4 new ones) or unknown substrates (2 new members), It is proposed that the latter family which has homologs in Tetrahymena thermophila, Plasmodium falciparum and Caenorhabditis elegans constitutes a new group called P4-ATPases with characteristic topology and aminoacid signatures. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:325 / 332
页数:8
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