Safe and fast tetrazole formation in ionic liquids

被引：66

作者：

Schmidt, Boris ^{[1
]}

Meid, Daniela ^{[1
]}

Kieser, Daniel ^{[1
]}

机构：

[1] Tech Univ Darmstadt, Clemens Schopf Inst Organ Chem & Biochem, D-64287 Darmstadt, Germany

来源：

TETRAHEDRON | 2007年 / 63卷 / 02期

关键词：

D O I：

10.1016/j.tet.2006.10.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The [2+3] cycloaddition of nitriles and azides is reliable for intramolecular reactions, but the hazards with volatile azides in intermolecular reactions are tremendous. Zinc catalysis in aqueous solution is a magnificent improvement, but requires the removal of the zinc salts from the acidic product. Herein, we report safe solvents featuring low vapor pressure and good solubility of NaN3. Ionic liquids based on alkylated imidazoles combined with microwave heating turned out to be a solution for the given tasks. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：492 / 496

页数：5

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