Recombinant bone morphogenic protein-2 in orthopaedic surgery: a review

被引：46

作者：

Valdes, Mauricio A. ^{[3
]}

Thakur, Nikhil A. ^{[3
]}

Namdari, Surena ^{[2
]}

Ciombor, Deborah M. ^{[3
]}

Palumbo, Mark ^{[1
,3
]}

机构：

[1] Univ Orthoped, Providence, RI 02905 USA

[2] Univ Penn, Dept Orthopaed, Philadelphia, PA 19104 USA

[3] Brown Univ, Rhode Isl Hosp, Dept Orthopaed, Warren Alpert Med Sch, Providence, RI 02903 USA

来源：

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | 2009年 / 129卷 / 12期

关键词：

Bone morphogenic protein; Spine fusion; Bone healing; Growth factors; Open fractures; LUMBAR INTERBODY FUSION; OPEN TIBIAL FRACTURES; PROTEIN-2/COMPRESSION RESISTANT MATRIX; OSTEOINDUCTIVE GROWTH-FACTOR; SEGMENTAL FEMORAL DEFECTS; SPINAL-FUSION; CLINICAL-EVALUATION; AUTOGRAFT BONE; BASIC SCIENCE; RHBMP-2;

D O I：

10.1007/s00402-009-0850-8

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Bone morphogenic proteins (BMPs) are pleiotropic regulators of bone volume, skeletal organogenesis and bone regeneration after a fracture. They function as signaling agents to affect cellular events like proliferation, differentiation and extracellular matrix synthesis. Clinically utilized rhBMP-2 combines rhBMP-2 with an osteoconductive carrier to induce bone growth and acts as a bone graft substitute. rhBMP-2, initially released in 2002, has been used primarily in spinal fusions in the lumbar and cervical regions. Recently, the application of rhBMP-2 has extended into the orthopedic trauma setting with increased application in open tibia fractures. This review outlines the history of development, molecular characteristics, toxicity and clinical applications.

引用

页码：1651 / 1657

页数：7

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