Salicylate and quinine affect the central nervous system

被引：30

作者：

Kenmochi, M ^{[1
]}

Eggermont, JJ ^{[1
]}

机构：

[1] UNIV CALGARY,DEPT PSYCHOL,BEHAV NEUROSCI RES GRP,CALGARY,AB T2N 1N4,CANADA

来源：

HEARING RESEARCH | 1997年 / 113卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

cat; primary auditory cortex; single unit; local field potential; salicylate; quinine; tinnitus;

D O I：

10.1016/S0378-5955(97)00137-8

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Spontaneous local field potential (LFP) spindle frequencies in cat primary auditory cortex (AI) were estimated from the LFP-trigger autocorrelogram before and after application of sodium salicylate and quinine sulfate. A significant decrease (from 8.7 Hz to 7.6 Hz) was observed. The best modulation frequencies for 251 single units recorded in AI response to periodic click train stimulation also decreased (from 10 Hz to 8.6 Hz) after application of these tinnitus-inducing drugs. The results strongly suggest a central effect of salicylates and quinine in addition to their peripheral ototoxic effects.

引用

页码：110 / 116

页数：7

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