Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness

被引:98
作者
Palmer, LJ
Burton, PR
Faux, JA
James, AL
Musk, AW
Cookson, WOCM
机构
[1] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
[2] Univ Leicester, Dept Epidemiol & Publ Hlth, Genet Epidemiol Unit, Leicester, Leics, England
[3] John Radcliffe Hosp, Nuffield Dept Clin Med, Oxford OX3 9DU, England
[4] Univ Perth, Dept Med, Dept Pulm Physiol, Perth, WA, Australia
[5] Sir Charles Gairdner Hosp, Dept Resp Med, Perth, WA, Australia
[6] TVW Telethon Inst Child Hlth Res, Div Populat Sci, Genet Epidemiol Unit, Perth, WA, Australia
关键词
D O I
10.1164/ajrccm.161.6.9805104
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Elevated serum Immunoglobulin E (IgE) levels and increased airway responsiveness (AR) are correlated traits that are characteristic of asthma. It is not known to what extent these traits arise from distinct or shared genetic determinants. We investigated the genetic and environmental components of variance of serum total and specific IgE levels and AR in an Australian population-based sample of 232 Caucasian nuclear families. The inter-relationships of the genetic determinants of these traits were also investigated. Log, total serum IgE levels had a narrow-sense heritability (h(N)(2)) of 47.3% (SE = 10.0%). Specific serum IgE levels against house dust mite and timothy grass, measured as a RAST Index, ad a h(N)(2) Of 33.8% (SE = 7.3%). AR, quantified by the log, dose-response slope to methacholine (DRS), had a h(N)(2) of 30.0% (SE = 12.3%). Extended modeling demonstrated an approximate 70% overlap in the genetic determinants of total and specific serum IgE levels. The genetic determinants of serum IgE levels and AR exhibited less than 30% sharing. These data are consistent with the existence of multiple genetic determinants of the pathophysiologic traits associated with asthma, and suggest that AR is genetically distinct from atopy. These results have implications for gene discovery programs.
引用
收藏
页码:1836 / 1843
页数:8
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