Active sugar transport in health and disease

被引：500

作者：

Wright, E. M. ^{[1
]}

Hirayama, B. A. ^{[1
]}

Loo, D. F. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF INTERNAL MEDICINE | 2007年 / 261卷 / 01期

关键词：

diabetes; familial renal glucosuria; glucose-galactose malabsorption; Na/glucose cotransporters; NA+-GLUCOSE COTRANSPORTER; RECESSIVE RENAL GLUCOSURIA; CONFORMATIONAL-CHANGES; ELECTROGENIC PROPERTIES; NA+/GLUCOSE; BINDING; SGLT1; KINETICS; MUTATION; INHIBITION;

D O I：

10.1111/j.1365-2796.2006.01746.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being focused on SGLTs as drug targets for the therapy of diabetes.

引用

页码：32 / 43

页数：12

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