Time-dependent inhibition of neuronal nitric oxide synthase by N-propargylguanidine

被引：8

作者：

Fast, W

Huff, ME

Silverman, RB

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM,EVANSTON,IL 60208

[2] NORTHWESTERN UNIV,DEPT BIOCHEM MOL BIOL & CELL BIOL,EVANSTON,IL 60208

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)00241-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Propargylguanidine was synthesized and found to be a time-dependent inhibitor of neuronal nitric oxide synthase from bovine brain. No inactivation occurs when NADP(+) is substituted for NADPH, inhibition is blocked by L-arginine, but not D-arginine, and no enzyme reactivation occurs by dilution of inactivated enzyme with excess L-arginine. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：1449 / 1454

页数：6

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