The mechanism of non-homologous end-joining: a synopsis of synapsis

被引：160

作者：

Weterings, E ^{[1
]}

van Gent, DC ^{[1
]}

机构：

[1] Erasmus MC, Dept Cell Biol & Genet, NL-3000 DR Rotterdam, Netherlands

来源：

DNA REPAIR | 2004年 / 3卷 / 11期

关键词：

non-homologous end-joining; DNA double-strand-breaks;

D O I：

10.1016/j.dnarep.2004.06.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is required for resistance to genotoxic agents, such as ionizing radiation, but also for proper development of the vertebrate immune system. Much progress has been made in identifying the factors that are involved in this repair pathway. We are now entering the phase in which we begin to understand basic concepts of the reaction mechanism and regulation of non-homologous end-joining. This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：1425 / 1435

页数：11

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