Humanized mice in translational biomedical research

被引：969

作者：

Shultz, Leonard D.

Ishikawa, Fumihiko

Greiner, Dale L.

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

[2] RIKEN, Res Ctr Allergy & Immunol, Yokahama Inst, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

[3] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

引用

收藏

页码：118 / 130

页数：13

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