Immunological changes during treatment interruptions: risk factors and clinical sequelae

被引：26

作者：

Poulton, MB ^{[1
]}

Sabin, CA

Fisher, M

机构：

[1] Royal Sussex Cty Hosp, Brighton Hlth Care NHS Trust, Brighton BN2 5BE, E Sussex, England

[2] UCL Royal Free & Univ Coll, Sch Med, Dept Primary Care & Populat Sci, London NW3 2PF, England

来源：

AIDS | 2003年 / 17卷 / 01期

关键词：

D O I：

10.1097/00002030-200301030-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study highlights risk factors for CD4 cell losses and clinical consequences of antiretroviral treatment interruptions. The largest decreases in CD4 cell counts occur in patients with lower nadir CD4 cell counts or more advanced disease. Falls are greater in those with higher rates of CD4 cell loss before highly active antiretroviral therapy, and are associated with a significant increase in clinical/AIDS events during treatment interruption. Caution is therefore advised when considering treatment interruption in those with advanced disease.

引用

页码：126 / 128

页数：3

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