Interaction of supramolecular assembly with hairless rat stratum corneum

被引：22

作者：

Kamimura, W ^{[1
]}

Ooya, T ^{[1
]}

Yui, N ^{[1
]}

机构：

[1] JAPAN ADV INST SCI & TECHNOL, SCH MAT SCI, TATSUNOKUCHI, ISHIKAWA 92312, JAPAN

来源：

JOURNAL OF CONTROLLED RELEASE | 1997年 / 44卷 / 2-3期

关键词：

supramolecular assembly; polyrotaxane; stratum corneum; bound water; penetration enhancers;

D O I：

10.1016/S0168-3659(96)01530-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyrotaxanes are well known as a supramolecular assembly in which many cyclic compounds are threaded onto a linear polymeric chain capped with bulky end-groups. In this paper, a polyrotaxane consisting of alpha-CDs and PEG capped with biodegradable peptide moieties was synthesized, and the interaction with stratum corneum of hairless rat skin was examined by means of a differential scanning calorimetry. The hydroxypropylated polyrotaxane was found to interact with lipid components in the stratum corneum: bound water content was significantly decreased although ordered lipid bilayers were maintained. Thus, it is suggested that our designed polyrotaxane can be feasible as novel candidates for transdermal penetration enhancers.

引用

页码：295 / 299

页数：5

共 22 条

[1] NOVEL SILICONES FOR TRANSDERMAL THERAPEUTIC SYSTEM .2. PREPARATION OF OLIGODIMETHYLSILOXANES CONTAINING DIETHYL PHOSPHORAMIDATE GROUP AT THE CHAIN END AND THE EVALUATION AS TRANSDERMAL PENETRATION ENHANCERS [J].

AOYAGI, T ;

NAKAMURA, T ;

NAGASE, Y .

POLYMER JOURNAL, 1992, 24 (04) :375-381

[2] NOVEL SILICONES FOR TRANSDERMAL THERAPEUTIC SYSTEM .3. PREPARATION OF PYRIDINIO-TERMINATED OR AMMONIO-TERMINATED POLYDIMETHYLSILOXANES AND THE EVALUATION AS TRANSDERMAL PENETRATION ENHANCERS [J].

AOYAGI, T ;

NAKAMURA, T ;

YABUCHI, Y ;

NAGASE, Y .

POLYMER JOURNAL, 1992, 24 (06) :545-553

[3] ENHANCEMENT OF NALOXONE PENETRATION THROUGH HUMAN-SKIN INVITRO USING FATTY-ACIDS, FATTY ALCOHOLS, SURFACTANTS, SULFOXIDES AND AMIDES [J].

AUNGST, BJ ;

ROGERS, NJ ;

SHEFTER, E .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 33 (1-3) :225-234

[4]

AUNGST BJ, 1991, HIGH PERFORMANCE BIO, P527

[5] LIPID-PROTEIN-PARTITIONING THEORY OF SKIN PENETRATION ENHANCEMENT [J].

BARRY, BW .

JOURNAL OF CONTROLLED RELEASE, 1991, 15 (03) :237-248

[6] A SIMPLE-MODEL FOR PROTEINS WITH INTERACTING DOMAINS - APPLICATIONS TO SCANNING CALORIMETRY DATA [J].

BRANDTS, JF ;

HU, CQ ;

LIN, LN ;

MAS, MT .

BIOCHEMISTRY, 1989, 28 (21) :8588-8596

[7] PREPARATION AND PROPERTIES OF INCLUSION COMPLEXES OF POLY(ETHYLENE GLYCOL) WITH ALPHA-CYCLODEXTRIN [J].

HARADA, A ;

LI, J ;

KAMACHI, M .

MACROMOLECULES, 1993, 26 (21) :5698-5703

[8] PREPARATION AND CHARACTERIZATION OF POLYROTAXANES CONTAINING MANY THREADED ALPHA-CYCLODEXTRINS [J].

HARADA, A ;

LI, J ;

NAKAMITSU, T ;

KAMACHI, M .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (26) :7524-7528

[9] THE MOLECULAR NECKLACE - A ROTAXANE CONTAINING MANY THREADED ALPHA-CYCLODEXTRINS [J].

HARADA, A ;

LI, J ;

KAMACHI, M .

NATURE, 1992, 356 (6367) :325-327

[10] DIFFERENTIAL SCANNING CALORIMETRIC STUDIES ON THE MELTING BEHAVIOR OF WATER IN STRATUM-CORNEUM [J].

INOUE, T ;

TSUJII, K ;

OKAMOTO, K ;

TODA, K .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 86 (06) :689-693

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