The Optimal Timing of Hydrogel Injection for Treatment of Intervertebral Disc Degeneration Quantitative Analysis Based on T1ρ MR Imaging

被引：17

作者：

Liu, Zhiguo ^{[1
]}

Li, Jianwen ^{[2
]}

Hu, Minghsien ^{[3
,4
]}

Wang, Xiaoshuai ^{[5
]}

Chen, Ningning ^{[5
]}

Cui, Shangbin ^{[6
]}

Li, Songbo ^{[2
]}

Liu, Hanzhong ^{[5
]}

Chen, Guoliang ^{[5
]}

Pan, Ximin ^{[7
]}

Sun, Haixing ^{[8
]}

Liu, Shaoyu ^{[5
]}

Wei, Fuxin ^{[5
]}

机构：

[1] Shandong Univ, Dept Neurosurg, Peoples Hosp Zhangqiu, Shandong Prov Hosp, Jinan, Shandong, Peoples R China

[2] Southern Med Univ, Affiliated Dongguan Peoples Hosp, Dept Spine Surg, Dongguan, Peoples R China

[3] Show Chwan Mem Hosp, Dept Orthoped, Changhua, Taiwan

[4] Natl Yang Ming Univ, Fac Med, Dept Orthoped Surg, Taipei, Taiwan

[5] Sun Yat Sen Univ, Dept Orthopaed, Affiliated Hosp 7, Shenzhen 518100, Guangdong, Peoples R China

[6] Sun Yat Sen Univ, Dept Spine Surg, Affiliated Hosp 1, Guangzhou, Peoples R China

[7] Sun Yat Sen Univ, Dept Radiol, Affiliated Hosp 6, Guangzhou, Peoples R China

[8] Sun Yat Sen Univ, Dept Radiol, Affiliated Hosp 1, Guangzhou, Peoples R China

来源：

SPINE | 2020年 / 45卷 / 22期

基金：

中国国家自然科学基金;

关键词：

animal model; biocompatible hydrogel; biological therapy; degeneration; intervertebral disc; lumbar; optimal time; regeneration; T1 rho magnetic resonance imaging; treatment;

D O I：

10.1097/BRS.0000000000003667

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Study Design. Animal experimental study. Objective. The aim of this study was to investigate the optimal time of hydrogel injection for regenerating intervertebral disc degeneration (IDD) based on T1 rho magnetic resonance imaging (MRI). Summary of Background Data. Currently, different approaches are being pursued to regenerate the IDD. However, the optimal timing for the regenerative intervention is unclear. Methods. The slowly, progressive IDD models were established in 18 rhesus monkeys. On the basis of the MR T1 rho values of the discs, the rhesus monkeys were divided into severe (T1 rho values: <81 ms), moderate (T1 rho values: 81 similar to 95 ms), and mild (T1 rho values: 96 similar to 110 ms) degeneration groups. Biocompatible hydrogel was injected into the central part of the nucleus pulposus of the discs under fluoroscopic guidance. Treatment effects were investigated using radiography, T1 rho MRI, and histology until 12 months postoperatively. Results. After injection, the T1 rho values of all the discs increased significantly at 1 month postoperatively, and then remained at approximately 110 ms in the mild and moderate groups during the whole observation period, with no significant difference compared to the values at 1 month (P> 0.05). However, in the severe group, the T1 rho values decreased significantly after 1 month and leveled at approximately 70 ms after 6 months, with significant difference compared to the values at 1 month (P< 0.05). In the mild and moderate groups, there were no significant differences between preoperative histological scores and those at 12 months (P> 0.05). However, the histological score in the severe group at 12 months was significantly higher than the preoperative scores (P< 0.05). Conclusion. This study suggested that the moderate degenerative stage of IDD (T1 rho values from 95 to 80 ms) could be the optimal time for hydrogel injection aimed at the regenerative intervention, based on T1 rho-MR imaging technique and quantitative analysis.

引用

页码：E1451 / E1459

页数：9

共 39 条

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