Serum thrombopoietin levels in patients with aplastic anaemia

被引:94
作者
Marsh, JCW
Gibson, FM
Prue, RL
Bowen, A
Dunn, VT
Hornkohl, AC
Nichol, JL
GordonSmith, EC
机构
[1] ST GEORGE HOSP,SCH MED,DEPT CELLULAR & MOL SCI,DIV HAEMATOL,LONDON SW17 0RE,ENGLAND
[2] AMGEN INC,THOUSAND OAKS,CA 91320
关键词
thrombopoietin; TPO; aplastic anaemia;
D O I
10.1046/j.1365-2141.1996.d01-1966.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Endogenous serum thrombopoietin (TPO) levels were measured in 31 patients with aplastic anaemia (AA) using an enzyme immunoassay with a sensitivity of 20 pg/ ml. The median platelet count for all AA patients was 30+/- 29 x 10(9)/l (range 5-102) compared with a median of 284+/-59 x 10(9)/l (range 148-538) for normal controls. Serum TPO levels were significantly elevated in all patients compared with normals (1706+/-1114.2, range 375-5000 v 78+/-54, range 16.5-312.9, P < 0.0001). There was no correlation between serum TPO levels and the degree of thrombocytopenia in AA patients, but TPO levels were significantly higher in patients who were platelet transfusion dependent than in patients who were transfusion independent (P < 0.01). There was a trend for higher TPO levels in patients with severe AA compared with non-severe AA patients. Clinical trials of TPO and a related truncated, pegylated molecule, megakaryocyte growth and development factor (PEG-rHuMGDF), are awaited to determine whether treatment with these drugs will result in increased platelet counts in patients with AA.
引用
收藏
页码:605 / 610
页数:6
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