Dynamics of DNA methylation pattern

被引：82

作者：

Hsieh, CL ^{[1
]}

机构：

[1] Univ So Calif, Dept Urol, Norris Cotton Canc Ctr, Los Angeles, CA 90033 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(00)00064-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Methylation patterns are the result of de novo methylation, demethylation, and the maintenance of existing methylation. Although the existence and identity of an active demethylase remain in doubt, recent evidence suggests that protein binding can specify sites of demethylation through a replication-dependent pathway. By using a stable episomal system in human cells, plus the Drosophila system, and mouse embryonic stem cells, we are beginning to understand the function and targets of de novo methyltransferases in murine and human cells.

引用

页码：224 / 228

页数：5

共 35 条

[1] A mammalian protein with specific demethylase activity for mCpG DNA [J].

Bhattacharya, SK ;

Ramchandani, S ;

Cervoni, N ;

Szyf, M .

NATURE, 1999, 397 (6720) :579-583

[2] DNA demethylase is a processive enzyme [J].

Cervoni, N ;

Bhattacharya, S ;

Szyf, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) :8363-8366

[3]

Doerfler W., 1993, DNA METHYLATION MOL, P262

[4] IS HYPOMETHYLATION LINKED TO ACTIVATION OF DELTA-CRYSTALLIN GENES DURING LENS DEVELOPMENT [J].

GRAINGER, RM ;

HAZARDLEONARDS, RM ;

SAMAHA, F ;

HOUGAN, LM ;

LESK, MR ;

THOMSEN, GH .

NATURE, 1983, 306 (5938) :88-91

[5] The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome [J].

Hansen, RS ;

Wijmenga, C ;

Luo, P ;

Stanek, AM ;

Canfield, TK ;

Weemaes, CMR ;

Gartler, SM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (25) :14412-14417

[6]

HASSE A, 1994, J BIOL CHEM, V269, P1821

[7] Identification and characterization of a family of mammalian methyl-CpG binding proteins [J].

Hendrich, B ;

Bird, A .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6538-6547

[8] The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites [J].

Hendrich, B ;

Hardeland, U ;

Ng, HH ;

Jiricny, J ;

Bird, A .

NATURE, 1999, 401 (6750) :301-304

[9] Factors affecting de novo methylation of foreign DNA in mouse embryonic stem cells [J].

Hertz, JM ;

Schell, G ;

Doerfler, W .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :24232-24240

[10]

Hsieh CL, 1999, MOL CELL BIOL, V19, P8211

← 1 2 3 4 →