共 125 条
Peroxisome proliferator-activated receptors at the crossroads of obesity, diabetes, and cardiovascular disease
被引:27
作者:

Gilde, Andries J.
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机构: Inst Pasteur, INSERM, U545, F-59019 Lille, France

Fruchart, Jean-Charles
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h-index: 0
机构: Inst Pasteur, INSERM, U545, F-59019 Lille, France

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h-index:
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机构:
[1] Inst Pasteur, INSERM, U545, F-59019 Lille, France
[2] Inst Pasteur, Dept Atherosclerosis, F-59019 Lille, France
[3] Univ Lille 2, F-59800 Lille, France
关键词:
D O I:
10.1016/j.jacc.2006.04.097
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Since their discovery in the early 1990s, the members of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors have been recognized as therapeutic targets against dyslipidemia and diabetes. Recent studies also identified anti-inflammatory actions of PPARs in cells constituting the atherosclerotic lesion. Delineation of this activity extended the therapeutic potential of PPAR activators beyond their original design as metabolic controllers. The PPAR family consists of 3 PPAR isoforms: alpha, beta/delta, and gamma, which exert different and sometimes overlapping effects on whole-body physiology in particular on lipid and glucose metabolism. This review summarizes the current knowledge on the role of PPARs in cardiovascular disease, the metabolic syndrome, atherosclerosis, and cardiac function.
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页码:A24 / A32
页数:9
相关论文
共 125 条
[41]
PPARα inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a
[J].
Gizard, F
;
Amant, C
;
Barbier, O
;
Bellosta, S
;
Robillard, R
;
Percevault, F
;
Sevestre, H
;
Krimpenfort, P
;
Corsini, A
;
Rochette, J
;
Glineur, C
;
Fruchart, JC
;
Torpier, G
;
Staels, B
.
JOURNAL OF CLINICAL INVESTIGATION,
2005, 115 (11)
:3228-3238

Gizard, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Amant, C
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Barbier, O
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Bellosta, S
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Robillard, R
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Percevault, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Sevestre, H
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Krimpenfort, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

论文数: 引用数:
h-index:
机构:

Rochette, J
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Glineur, C
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Fruchart, JC
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Torpier, G
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France

Staels, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM, U545, Dept Atherosclerose, F-59019 Lille, France
[42]
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
[J].
Goldberg, RB
;
Kendall, DM
;
Deeg, MA
;
Buse, JB
;
Zagar, AJ
;
Pinaire, JA
;
Tan, MH
;
Khan, MA
;
Perez, AT
;
Jacober, SJ
.
DIABETES CARE,
2005, 28 (07)
:1547-1554

Goldberg, RB
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Kendall, DM
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Deeg, MA
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Buse, JB
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Zagar, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Pinaire, JA
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Tan, MH
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Khan, MA
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Perez, AT
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA

Jacober, SJ
论文数: 0 引用数: 0
h-index: 0
机构: Lilly Corp Ctr, A Div Eli Lilly, Lilly Res Labs, Indianapolis, IN 46285 USA
[43]
Activation of peroxisome proliferator-activated receptor-α and -γ in auricular tissue from heart failure patients
[J].
Gómez-Garre, D
;
Herraíz, M
;
González-Rubio, ML
;
Bernal, R
;
Aragoncillo, P
;
Carbonell, A
;
Rufilanchas, JJ
;
Fernández-Cruz, A
.
EUROPEAN JOURNAL OF HEART FAILURE,
2006, 8 (02)
:154-161

Gómez-Garre, D
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

Herraíz, M
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

González-Rubio, ML
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

Bernal, R
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

Aragoncillo, P
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

Carbonell, A
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

Rufilanchas, JJ
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain

Fernández-Cruz, A
论文数: 0 引用数: 0
h-index: 0
机构: UCM, Lab Biol Vasc & Arteriosclerosis Med Nucl Sontano, Dept Pathol, Hosp Clin San Carlos, Madrid 28040, Spain
[44]
Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity
[J].
Guerre-Millo, M
;
Gervois, P
;
Raspé, E
;
Madsen, L
;
Poulain, P
;
Derudas, B
;
Herbert, JM
;
Winegar, DA
;
Willson, TM
;
Fruchart, JC
;
Berge, RK
;
Staels, B
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2000, 275 (22)
:16638-16642

Guerre-Millo, M
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Gervois, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Raspé, E
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Madsen, L
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Poulain, P
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Derudas, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Herbert, JM
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Winegar, DA
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Willson, TM
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Fruchart, JC
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Berge, RK
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France

Staels, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Biomed Cordeliers, INSERM, U465, F-75006 Paris, France
[45]
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth
[J].
Gupta, RA
;
Wang, DZ
;
Katkuri, S
;
Wang, HB
;
Dey, SK
;
DuBois, RN
.
NATURE MEDICINE,
2004, 10 (03)
:245-247

Gupta, RA
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

Wang, DZ
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

Katkuri, S
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

Wang, HB
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

Dey, SK
论文数: 0 引用数: 0
h-index: 0
机构: Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA

DuBois, RN
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA
[46]
Missense variants in the human peroxisome proliferator-activated receptor-γ2 gene in lean and obese subjects
[J].
Hamann, A
;
Münzberg, H
;
Buttron, P
;
Büsing, B
;
Hinney, A
;
Mayer, H
;
Siegfried, W
;
Hebebrand, J
;
Greten, H
.
EUROPEAN JOURNAL OF ENDOCRINOLOGY,
1999, 141 (01)
:90-92

Hamann, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Münzberg, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Buttron, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Büsing, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Hinney, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Mayer, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Siegfried, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Hebebrand, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany

Greten, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hamburg, Krankenhaus Eppendorf, Med Kernklin & Poliklin, D-20246 Hamburg, Germany
[47]
Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis
[J].
Harman, FS
;
Nicol, CJ
;
Marin, HE
;
Ward, JM
;
Gonzalez, FJ
;
Peters, JM
.
NATURE MEDICINE,
2004, 10 (05)
:481-483

Harman, FS
论文数: 0 引用数: 0
h-index: 0
机构: Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

Nicol, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

Marin, HE
论文数: 0 引用数: 0
h-index: 0
机构: Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

Ward, JM
论文数: 0 引用数: 0
h-index: 0
机构: Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

Gonzalez, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

Peters, JM
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA
[48]
Obesity
[J].
Haslam, DW
;
James, WPT
.
LANCET,
2005, 366 (9492)
:1197-1209

Haslam, DW
论文数: 0 引用数: 0
h-index: 0
机构:
Watton Pl Clin, Natl Obes Forum, Watton At Stone SG14 3SY, Herts, England Watton Pl Clin, Natl Obes Forum, Watton At Stone SG14 3SY, Herts, England

James, WPT
论文数: 0 引用数: 0
h-index: 0
机构: Watton Pl Clin, Natl Obes Forum, Watton At Stone SG14 3SY, Herts, England
[49]
Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
[J].
He, WM
;
Barak, Y
;
Hevener, A
;
Olson, P
;
Liao, D
;
Le, J
;
Nelson, M
;
Ong, E
;
Olefsky, JM
;
Evans, RM
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2003, 100 (26)
:15712-15717

He, WM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Barak, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Hevener, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Olson, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Liao, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Le, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Nelson, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Ong, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Olefsky, JM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

Evans, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[50]
Peroxisome proliferator-activated receptor (PPAR) activation induces tissue-specific effects on fatty acid uptake and metabolism in vivo -: A study using the novel PPARα/γ agonist tesaglitazar
[J].
Hegarty, BD
;
Furler, SM
;
Oakes, ND
;
Kraegen, EW
;
Cooney, GJ
.
ENDOCRINOLOGY,
2004, 145 (07)
:3158-3164

Hegarty, BD
论文数: 0 引用数: 0
h-index: 0
机构: St Vincents Hosp, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia

Furler, SM
论文数: 0 引用数: 0
h-index: 0
机构: St Vincents Hosp, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia

Oakes, ND
论文数: 0 引用数: 0
h-index: 0
机构: St Vincents Hosp, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia

Kraegen, EW
论文数: 0 引用数: 0
h-index: 0
机构: St Vincents Hosp, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia

Cooney, GJ
论文数: 0 引用数: 0
h-index: 0
机构: St Vincents Hosp, Garvan Inst Med Res, Diabet & Obes Res Program, Sydney, NSW 2010, Australia