Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model

被引：26

作者：

Ma, Yunglin D. ^{[1
,2
]}

Park, Changwon ^{[1
]}

Zhao, Haibo ^{[1
]}

Oduro, Kwadwo A., Jr. ^{[1
,2
,3
]}

Tu, Xiaolin ^{[4
]}

Long, Fanxin ^{[4
]}

Allen, Paul M. ^{[1
]}

Teitelbaum, Steven L. ^{[1
]}

Choi, Kyunghee ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dev Biol Program, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Med Sci Training Program, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

来源：

BLOOD | 2009年 / 114卷 / 20期

基金：

美国国家卫生研究院;

关键词：

COMMON LYMPHOID PROGENITORS; BONE-MARROW; RHEUMATOID-ARTHRITIS; ADHESION MOLECULE-1; B-LYMPHOPOIESIS; SELF-RENEWAL; POOL SIZE; NICHE; DIFFERENTIATION; IDENTIFICATION;

D O I：

10.1182/blood-2008-12-196311

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis in normal steady states. Using mice undergoing chronic inflammatory arthritis, we investigated the relationship between hematopoiesis and bone homeostasis in pathologic conditions. We demonstrate that mice undergoing chronic inflammatory arthritis displayed osteoporosis resulting from a severe defect in osteoblast function. Despite the defective osteoblast function, however, the hematopoietic stem cells from these mice exhibited normal properties in either long-term repopulation or cell cycling. Therefore, the bone-forming capacity of osteoblasts is distinct from their ability to maintain hematopoietic stem cells in chronic inflammatory conditions. (Blood. 2009;114:4402-4410)

引用

页码：4402 / 4410

页数：9

共 43 条

[1]

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche [J].

Arai, F ;

Hirao, A ;

Ohmura, M ;

Sato, H ;

Matsuoka, S ;

Takubo, K ;

Ito, K ;

Koh, GY ;

Suda, T .

CELL, 2004, 118 (02) :149-161

[2]

Aubin JE, 1996, MICROSC RES TECHNIQ, V33, P128, DOI 10.1002/(SICI)1097-0029(19960201)33:2<128::AID-JEMT4>3.0.CO

[3]

2-P

[4]

Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[5]

Stem cell repopulation efficiency but not pool size is governed by p27kip1 [J].

Cheng, T ;

Rodrigues, N ;

Dombkowski, D ;

Stier, S ;

Scadden, DT .

NATURE MEDICINE, 2000, 6 (11) :1235-1240

[6]

RESOLUTION AND CHARACTERIZATION OF PRO-B AND PRE-PRO-B CELL STAGES IN NORMAL MOUSE BONE-MARROW [J].

HARDY, RR ;

CARMACK, CE ;

SHINTON, SA ;

KEMP, JD ;

HAYAKAWA, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (05) :1213-1225

[7]

Inflammatory cells and bone loss in rheumatoid arthritis [J].

Haynes, David R. .

ARTHRITIS RESEARCH & THERAPY, 2007, 9 (03)

[8]

Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages [J].

Karsunky, Holger ;

Inlay, Matthew A. ;

Serwold, Thomas ;

Bhattacharya, Deepta ;

Weissman, Irving L. .

BLOOD, 2008, 111 (12) :5562-5570

[9]

Maintaining hematopoietic stem cells in the vascular niche [J].

Kiel, Mark J. ;

Morrison, Sean J. .

IMMUNITY, 2006, 25 (06) :862-864

[10]

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells [J].

Kiel, MJ ;

Yilmaz, ÖH ;

Iwashita, T ;

Yilmaz, OH ;

Terhorst, C ;

Morrison, SJ .

CELL, 2005, 121 (07) :1109-1121

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