The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver

被引：25

作者：

Yokoyama, A

Karasaki, H

Urushibara, N

Nomoto, K

Imai, Y

Nakamura, K

Mizuno, Y

Ogawa, K

Kikuchi, K

机构：

[1] HOKKAIDO UNIV,INST IMMUNOL SCI,BIOCHEM SECT,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

[2] ASAHIKAWA MED COLL,DEPT PATHOL 1,ASAHIKAWA,HOKKAIDO 078,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 239卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.7547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

mRNA levels of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-2, mere determined during chemical hepatocarcinogenesis and during regeneration of rat liver, In chemical hepatocarcinogenesis, the mRNA levels of MKP-1 were increased in primary hepatomas but decreased in rat ascites hepatomas. as compared with normal liver. MKP-2 was undetectable in normal liver but strongly expressed ill hepatomas, The MKP-2 mRNA level was increased with expression of malignant phenotypes in hepatomas. In regenerating liver, the mRNA level of MKP-1 increased immediately but transiently after partial hepatectomy, and peaked again on day 10, the time when hepatocytes cease proliferation, The elevated expression of MKP-1 on day 10 suggests some roles of MKP-1 as a negative regulator in hepatocyte proliferation. (C) 1997 Academic Press.

引用

页码：746 / 751

页数：6

共 26 条

[1] Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts
Bokemeyer, D
Sorokin, A
Yan, MH
Ahn, NG
Templeton, DJ
Dunn, MJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) : 639 - 642
[2] BRONDELLO JM, 1995, ONCOGENE, V10, P1895
[3] The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
Chu, YF
Solski, PA
KhosraviFar, R
Der, CJ
Kelly, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (11) : 6497 - 6501
[4] MITOGEN-ACTIVATED PROTEIN (MAP) KINASE IS REGULATED BY THE MAP KINASE PHOSPHATASE (MKP-1) IN VASCULAR SMOOTH-MUSCLE CELLS
DUFF, JL
MONIA, BP
BERK, BC
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) : 7161 - 7166
[5] ISOLATION AND CHARACTERIZATION OF A NOVEL DUAL SPECIFIC PHOSPHATASE, HVH2, WHICH SELECTIVELY DEPHOSPHORYLATES THE MITOGEN-ACTIVATED PROTEIN-KINASE
GUAN, KL
BUTCH, E
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) : 7197 - 7203
[6] Higgins GM, 1931, ARCH PATHOL, V12, P186
[7] Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
Ichijo, H
Nishida, E
Irie, K
tenDijke, P
Saitoh, M
Moriguchi, T
Takagi, M
Matsumoto, K
Miyazono, K
Gotoh, Y
[J]. SCIENCE, 1997, 275 (5296) : 90 - 94
[8] ISHIBASHI T, 1994, J BIOL CHEM, V269, P29897
[9] King AG, 1995, ONCOGENE, V11, P2553
[10] MESSENGER-RNA LEVELS OF CATALYTIC SUBUNITS OF PROTEIN PHOSPHATASE-1, PHOSPHATASE-2A, AND PHOSPHATASE-2C IN HEPATOCARCINOGENESIS
KITAMURA, K
MIZUNO, Y
HATAYAMA, I
SATO, K
TAMURA, S
NAGAO, M
TSUIKI, S
KIKUCHI, K
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1992, 83 (01): : 66 - 71

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