Heteronuclear NOE analysis of bilirubin solution conformation and intramolecular hydrogen bonding

被引：52

作者：

Dorner, T ^{[1
]}

Knipp, B ^{[1
]}

Lightner, DA ^{[1
]}

机构：

[1] UNIV NEVADA,DEPT CHEM,RENO,NV 89557

来源：

TETRAHEDRON | 1997年 / 53卷 / 08期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4020(97)00045-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

H-1{H-1}-Homonuclear and C-13 {H-1}-heteronuclear NOE (Nuclear Overhauser Effect) experiments carried out on bilirubin analogs (1-5) in CDCl3 and in CDCl3-(CD3)(2)SO solutions indicate that the carboxylic acid groups and dipyrrinone lactams and/or pyrroles are linked by intramolecular hydrogen bonding. Nonbonded C-H to H-C and N-H to H-N, and N-H to CO2H distances were calculated from the NOE data and confirm that the bilirubins adopt a folded, ridge-tile shape in solution. (C) 1997 Elsevier Science Ltd.

引用

页码：2697 / 2716

页数：20

共 31 条

[1] BILIRUBIN METABOLISM AND THE HEREDITARY HYPERBILIRUBINEMIAS - INTRODUCTION [J].