Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant

被引：91

作者：

Prinarakis, EE

Miriagou, V

Tzelepi, E

Gazouli, M

Tzouvelekis, LS

机构：

[1] HELLENIC PASTEUR INST,DEPT BACTERIOL,ATHENS 11521,GREECE

[2] HELLENIC PASTEUR INST,QUAL CONTROL LAB,ATHENS 11521,GREECE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 04期

关键词：

D O I：

10.1128/AAC.41.4.838

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-130-->Gly mutant of the prototype SHV-5, obtained by site-directed mutagenesis, had properties similar to those of SHV-10.

引用

收藏

页码：838 / 840

页数：3

相关论文

共 20 条

[1] A STANDARD NUMBERING SCHEME FOR THE CLASS-A BETA-LACTAMASES [J].

AMBLER, RP ;

COULSON, AFW ;

FRERE, JM ;

GHUYSEN, JM ;

JORIS, B ;

FORSMAN, M ;

LEVESQUE, RC ;

TIRABY, G ;

WALEY, SG .

BIOCHEMICAL JOURNAL, 1991, 276 :269-270

[2]

BELAAOUAJ A, 1994, FEMS MICROBIOL LETT, V120, P75

[3] CHARACTERIZATION OF A NEW TEM-TYPE BETA-LACTAMASE RESISTANT TO CLAVULANATE, SULBACTAM, AND TAZOBACTAM IN A CLINICAL ISOLATE OF ESCHERICHIA-COLI [J].

BLAZQUEZ, J ;

BAQUERO, MR ;

CANTON, R ;

ALOS, I ;

BAQUERO, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (10) :2059-2063

[4] OHIO-1 BETA-LACTAMASE RESISTANT TO MECHANISM-BASED INACTIVATORS [J].

BONOMO, RA ;

CURRIEMCCUMBER, C ;

SHLAES, DM .

FEMS MICROBIOLOGY LETTERS, 1992, 92 (01) :79-82

[5] A FUNCTIONAL CLASSIFICATION SCHEME FOR BETA-LACTAMASES AND ITS CORRELATION WITH MOLECULAR-STRUCTURE [J].

BUSH, K ;

JACOBY, GA ;

MEDEIROS, AA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (06) :1211-1233

[6] Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2) [J].

Gazouli, M ;

Tzouvelekis, LS ;

Prinarakis, E ;

Miriagou, V ;

Tzelepi, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (07) :1736-1740

[7] SHV-5, A NOVEL SHV-TYPE BETA-LACTAMASE THAT HYDROLYZES BROAD-SPECTRUM CEPHALOSPORINS AND MONOBACTAMS [J].

GUTMANN, L ;

FERRE, B ;

GOLDSTEIN, FW ;

PINTOSCHUSTER, E ;

ACAR, JF ;

COLLATZ, E .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (06) :951-956

[8] MOLECULAR CHARACTERIZATION OF 9 DIFFERENT TYPES OF MUTANTS AMONG 107 INHIBITOR-RESISTANT TEM BETA-LACTAMASES FROM CLINICAL ISOLATES OF ESCHERICHIA-COLI [J].

HENQUELL, C ;

CHANAL, C ;

SIROT, D ;

LABIA, R ;

SIROT, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (02) :427-430

[9] A STRUCTURE-BASED ANALYSIS OF THE INHIBITION OF CLASS-A BETA-LACTAMASES BY SULBACTAM [J].

IMTIAZ, U ;

BILLINGS, EM ;

KNOX, JR ;

MOBASHERY, S .

BIOCHEMISTRY, 1994, 33 (19) :5728-5738

[10] INACTIVATION OF CLASS-A BETA-LACTAMASES BY CLAVULANIC ACID - THE ROLE OF ARGININE-244 IN A PROPOSED NONCONCERTED SEQUENCE OF EVENTS [J].

IMTIAZ, U ;

BILLINGS, E ;

KNOX, JR ;

MANAVATHU, EK ;

LERNER, SA ;

MOBASHERY, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (11) :4435-4442