RETRACTED: Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents (Retracted article. See vol. 423, pg. 154, 2018)

被引：25

作者：

Ali, Shadan ^{[2
]}

Varghese, Lalee ^{[1
]}

Pereira, Lucio ^{[3
]}

Tulunay-Ugur, Ozlem E. ^{[3
]}

Kucuk, Omer ^{[2
]}

Carey, Thomas E. ^{[4
]}

Wolf, Gregory T. ^{[4
]}

Sarkar, Fazlul H. ^{[1
]}

机构：

[1] Wayne State Univ, Dept Pathol, Karmanos Canc Ctr, Detroit, MI 48202 USA

[2] Wayne State Univ, Div Hematol Oncol, Karmanos Canc Ctr, Detroit, MI USA

[3] Wayne State Univ, Dept Otolaryngol, Karmanos Canc Ctr, Detroit, MI 48201 USA

[4] Univ Michigan, Dept Otolaryngol, Ann Arbor, MI 48109 USA

来源：

CANCER LETTERS | 2009年 / 278卷 / 02期

关键词：

Uterine cervix cancer; 3,3 '-Dindolylmethane; G2535; Cisplatin resistance; NF-kappa B; FACTOR-KAPPA-B; SOY ISOFLAVONE GENISTEIN; ENDOPLASMIC-RETICULUM STRESS; BREAST-CANCER CELLS; PANCREATIC-CANCER; NECK-CANCER; 3,3'-DIINDOLYLMETHANE DIM; CHEMOTHERAPEUTIC-AGENTS; CERVICAL-CANCER; ADVANCED HEAD;

D O I：

10.1016/j.canlet.2009.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin resistance is a major problem in the successful treatment of squamous cell carcinoma (SCC). In the present study we showed, for the first time, that the constitutive activation of NF-kappa B partly contributes to cisplatin resistance and that the inactivation of NF-kappa B by natural agents [G2535 (isoflavone mixture containing genistein and diadzein), 3,3'-diindolylmethane (Bioresponse BR-DIM referred to as B-DIM)] could overcome this resistance, resulting in the inhibition of cell growth and induction of apoptosis, which might be an useful strategy for achieving better treatment outcome in patients diagnosed with cisplatin-resistant tumors of SCC. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：201 / 209

页数：9

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