Hypertension and immunity: mechanisms of T cell activation and pathways of hypertension

被引：24

作者：

Abais-Battad, Justine M. ^{[1
]}

Rudemiller, Nathan P. ^{[1
]}

Mattson, David L. ^{[1
]}

机构：

[1] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2015年 / 24卷 / 05期

基金：

美国国家卫生研究院;

关键词：

hypertension; immunity; renal disease; T lymphocytes; PATHOGENIC T(H)17 CELLS; II-INDUCED HYPERTENSION; BLOOD-PRESSURE; OXIDATIVE STRESS; SODIUM-CHLORIDE; RENAL INJURY; HELPER; 17; KIDNEY; DISEASE; AUTOANTIBODIES;

D O I：

10.1097/MNH.0000000000000146

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Purpose of reviewThe role of immune mechanisms to amplify hypertension in patients and animal models has been appreciated for decades. This review briefly summarizes recent studies exploring the mechanistic pathways, whereby the immune system participates in hypertension and renal disease.Recent findingsEmphasis in this review is placed upon recent studies exploring the role of T cell subtypes, newly described mechanisms of T cell activation, the identification of potential neoantigens, and environmental influences on immune cell activation.SummarySignificant advancements have been made in the search for antigens and pathways responsible for activation of the adaptive immune response, furthering our understanding of the factors contributing to hypertension and potentially leading to the development of new and more effective therapies.

引用

页码：470 / 474

页数：5

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