The human selenoproteome: recent insights into functions and regulation

被引：384

作者：

Reeves, M. A. ^{[1
]}

Hoffmann, P. R. ^{[1
]}

机构：

[1] Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 15期

关键词：

Selenium; Selenoprotein; Selenocysteine; Antioxidant; Redox; CELLULAR GLUTATHIONE-PEROXIDASE; MITOCHONDRIAL THIOREDOXIN REDUCTASE; SELENOCYSTEINE INSERTION-SEQUENCE; CONGENITAL MUSCULAR-DYSTROPHY; GENE-EXPRESSION PROFILES; MESSENGER-RNA STABILITY; HUMAN TYPE-2 DEIODINASE; SELENOPHOSPHATE SYNTHETASE; PROSTATE-CANCER; TARGETED DISRUPTION;

D O I：

10.1007/s00018-009-0032-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selenium (Se) is a nutritional trace mineral essential for various aspects of human health that exerts its effects mainly through its incorporation into selenoproteins as the amino acid, selenocysteine. Twenty-five selenoprotein genes have been identified in humans and several selenoproteins are broadly classified as antioxidant enzymes. As progress is made on characterizing the individual members of this protein family, however, it is becoming clear that their properties and functions are quite diverse. This review summarizes recent insights into properties of individual selenoproteins such as tissue distribution, subcellular localization, and regulation of expression. Also discussed are potential roles the different selenoproteins play in human health and disease.

引用

页码：2457 / 2478

页数：22

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