Resistance phenotypes conferred by macrolide phosphotransferases

被引：39

作者：

Chesneau, Olivier ^{[1
]}

Tsvetkova, Krassimira ^{[1
]}

Courvalin, Patrice ^{[1
]}

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France

来源：

FEMS MICROBIOLOGY LETTERS | 2007年 / 269卷 / 02期

关键词：

phosphorylation; macrolide; ketolide; resistance; read-through;

D O I：

10.1111/j.1574-6968.2007.00643.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study aims to compare the resistance phenotypes conferred by various genes encoding enzymes that phosphorylate erythromycin. The mph genes were cloned into Escherichia coli AG100A susceptible to macrolides and ketolides following disruption of the AcrAB pump. An 882 bp sequence containing a premature stop codon, homologous to the three other previously described mph genes and present widely among Enterobacteriaceae, was found to confer resistance to erythromycin by phosphorylation. The mph(C) gene, as reported for mph(B), also conferred resistance to spiramycin. The mph(A) gene was unique in conferring resistance to azithromycin. The four investigated genes conferred resistance to telithromycin.

引用

页码：317 / 322

页数：6

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