Pharmaceutical Analysis for Environmental Samples: Individual and Simultaneous Determination of Ciprofloxacin, Ofloxacin and Norfloxacin Using an HPLC with Fluorescence and UV Detection with a Wetland Soil Matrix

被引：8

作者：

Conkle, J. L.

Lattao, C. V. ^{[2
,3
]}

White, J. R. ^{[1
]}

Cook, R. L. ^{[2
,3
]}

机构：

[1] Louisiana State Univ, Dept Oceanog & Coastal Sci, Wetland & Aquat Biogeochem Lab, Baton Rouge, LA 70803 USA

[2] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[3] So Univ Baton Rouge, Baton Rouge, LA USA

来源：

ANALYTICAL LETTERS | 2009年 / 42卷 / 18期

关键词：

Direct injection; fluoroquinolone; soil; PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; WASTE-WATER; MASS-SPECTROMETRY; FLUOROQUINOLONES; ANTIBIOTICS;

D O I：

10.1080/00032710903201883

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

Two HPLC methods were developed for individual and simultaneous determination of ciprofloxacin, norfloxacin and ofloxacin for use in laboratory experiments producing large numbers of samples (100s to 1000s). Individual compound detection produced retention times between 1.5 and 2min and simultaneous detection between 6.5 to 8min. The methods are compatible with complex geomatrices, e.g. a wetland soil. These methods provide 1) detection limits in the low parts per-billion range; 2) decrease in retention times of 5-10 times for single compounds, and up to 2 times for simultaneous detection over published methods; and 3) require no solid phase extraction.

引用

页码：2937 / 2950

页数：14

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