Endothelin-1 induces bronchial myofibroblast differentiation

被引：37

作者：

Sun, G

Stacey, MA

Bellini, A

Marini, M

Mattoli, S

机构：

[1] ITALIAN FDN EXPT MED,I-05100 TERNI,ITALY

[2] ITALIAN FDN EXPT MED,MILAN,ITALY

[3] ITALIAN FDN EXPT MED,ROME,ITALY

[4] INST EXPT MED,I-20144 MILAN,ITALY

[5] UNIV MILAN,DEPT PATHOL & EXPT BIOL,I-20133 MILAN,ITALY

来源：

PEPTIDES | 1997年 / 18卷 / 09期

关键词：

endothelin-1; airway epithelium; asthma; fibroblasts;

D O I：

10.1016/S0196-9781(97)00194-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts into myofibroblasts, and that they do so through a granulocyte/macrophage colony-stimulating factor-mediated upregulation of endothelin-l production. By this mechanism bronchial epithelial cells may participate ih the genesis of bronchial subepithelial fibrosis, a process which contributes to airway narrowing in asthma. (C) 1997 Elsevier Science Inc.

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收藏

页码：1449 / 1451

页数：3

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