Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists

被引：46

作者：

Ebert, Sandra ^{[1
]}

Zeretzke, Moritz ^{[1
]}

Nau, Roland ^{[1
]}

Michel, Uwe ^{[1
]}

机构：

[1] Univ Gottingen, Dept Neurol, D-37075 Gottingen, Germany

来源：

NEUROSCIENCE LETTERS | 2007年 / 413卷 / 03期

关键词：

activin A; follistatin; microglia; peritoneal macrophages; meningitis; toll-like receptors;

D O I：

10.1016/j.neulet.2006.11.065

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activin A levels are elevated in the cerebrospinal fluid (CSF) of patients with meningitis and in the sera of patients with sepsis. The source(s) of the elevated concentrations of activin A in CSF and serum have not yet been discovered. Here we demonstrate that primary mouse microglial cells and peritoneal macrophages release activin A after treatment with agonists of Toll-like receptor (TLR) 2, 4, and 9. These findings provide further evidence for a role of activin in the innate immune response and suggest that microglial cells and macrophages are a source of elevated activin A concentrations observed in the CSF during bacterial meningitis and in the systemic circulation during sepsis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：241 / 244

页数：4

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