Genomic interactions: Chromatin loops and gene meeting points in transcriptional regulation

被引：92

作者：

Sexton, Tom ^{[1
]}

Bantignies, Frederic ^{[1
]}

Cavalli, Giacomo ^{[1
]}

机构：

[1] CNRS, UPR 1142, Inst Human Genet, F-34396 Montpellier, France

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 07期

关键词：

Nuclear organisation; Genomic interactions; Epigenetic regulation; Review; BETA-GLOBIN LOCUS; CHROMOSOME CONFORMATION CAPTURE; NUCLEAR ARCHITECTURE; X-INACTIVATION; CONTROL REGION; INTERCHROMOSOMAL ASSOCIATIONS; INTERPHASE NUCLEUS; RESPONSE ELEMENTS; ACTIVE CHROMATIN; CTCF-BINDING;

D O I：

10.1016/j.semcdb.2009.06.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The chromosome conformation capture (3C) technique and its genome-wide applications ('4C') have identified a plethora of distal DNA sequences that are frequently in close spatial proximity. In many cases, these have been correlated with transcriptional regulation of the interacting genes, but the functional significance of many of the extreme long-range and interchromosomal interactions remains unclear. This review summarises our current understanding of how chromatin conformation can impinge on gene expression, the major questions that need to be addressed to understand this more fully, and how these questions may be answered in the near future. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：849 / 855

页数：7

共 73 条

[1] Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription [J].

Amano, Takanori ;

Sagai, Tomoko ;

Tanabe, Hideyuki ;

Mizushina, Yoichi ;

Nakazawa, Hiromi ;

Shiroishi, Toshihiko .

DEVELOPMENTAL CELL, 2009, 16 (01) :47-57

[2] Virus infection induces NF-κB-dependent interchromosomal associations mediating monoallelic IFN-β gene expression [J].

Apostolou, Effie ;

Thanos, Dimitris .

CELL, 2008, 134 (01) :85-96

[3] Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic [J].

Augui, S. ;

Filion, G. J. ;

Huart, S. ;

Nora, E. ;

Guggiari, M. ;

Maresca, M. ;

Stewart, A. F. ;

Heard, E. .

SCIENCE, 2007, 318 (5856) :1632-1636

[4]

Bacher CP, 2006, NAT CELL BIOL, V8, P293, DOI 10.1038/ncb1365

[5] EXPRESSION OF A BETA-GLOBIN GENE IS ENHANCED BY REMOTE SV40 DNA-SEQUENCES [J].

BANERJI, J ;

RUSCONI, S ;

SCHAFFNER, W .

CELL, 1981, 27 (02) :299-308

[6] Inheritance of Polycomb-dependent chromosomal interactions in Drosophila [J].

Bantignies, F ;

Grimaud, C ;

Lavrov, S ;

Gabut, M ;

Cavalli, G .

GENES & DEVELOPMENT, 2003, 17 (19) :2406-2420

[7] Protein:protein interactions and the pairing of boundary elements in vivo [J].

Blanton, J ;

Gaszner, M ;

Schedl, P .

GENES & DEVELOPMENT, 2003, 17 (05) :664-675

[8] High-resolution mapping and characterization of open chromatin across the genome [J].

Boyle, Alan P. ;

Davis, Sean ;

Shulha, Hennady P. ;

Meltzer, Paul ;

Margulies, Elliott H. ;

Weng, Zhiping ;

Furey, Terrence S. ;

Crawford, Gregory E. .

CELL, 2008, 132 (02) :311-322

[9] SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes [J].

Cai, Shutao ;

Lee, Charles C. ;

Kohwi-Shigematsu, Terumi .

NATURE GENETICS, 2006, 38 (11) :1278-1288

[10] Tissue-specific nuclear architecture and gene expession regulated by SATB1 [J].

Cai, ST ;

Han, HJ ;

Kohwi-Shigematsu, T .

NATURE GENETICS, 2003, 34 (01) :42-51

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