The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovir-naive patients

被引：25

作者：

Winston, A ^{[1
]}

Mandalia, S ^{[1
]}

Pillay, D ^{[1
]}

Gazzard, B ^{[1
]}

Pozniak, A ^{[1
]}

机构：

[1] Chelsea & Westminster Hosp, Dept Genitourinary HIV Med, London SW10 9NH, England

来源：

AIDS | 2002年 / 16卷 / 15期

关键词：

D O I：

10.1097/00002030-200210180-00018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The K65R mutation in HIV-1 reverse transcriptase is associated with reduced susceptibility to abacavir and tenofovir. We established its prevalence within a large clinical database, and investigated correlations with other resistance-associated mutations and antiretroviral history. The presence of K65R is associated with previous abacavir use. Although rare, it is preferentially selected within non-thymidine analogue-containing regimens, compared with concurrent zidovudine or stavudine use, which is associated with thymidine analogue mutations. Both genetic routes may compromise abacavir and tenofovir activity.

引用

页码：2087 / 2089

页数：3