Premature ovarian failure

被引：16

作者：

Christin-Maitre, S. ^{[1
]}

Pasquier, M. ^{[1
]}

Donadille, B. ^{[1
]}

Bouchard, P. ^{[1
]}

机构：

[1] Univ Paris 06, Assistance Publ Hop Paris, Reprod Endocrinol Serv, EA 1533, F-75012 Paris, France

来源：

ANNALES D ENDOCRINOLOGIE | 2006年 / 67卷 / 06期

关键词：

premature ovarian failure; ovary; X chromosome; FMR1;

D O I：

10.1016/S0003-4266(06)73007-4

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Premature ovarian failure (POF) is defined by at least four months of amenorrhea with elevated gonadotropins (usually above 40UI/L) detected on two occasions a few weeks apart, in a woman before the age of 40. It occurs in 1 out of 10,000 in women below the age of 20, 1/1,000 below 30 and 1% in women before the age of 40. In 80% of POF cases, the etiology is unknown, except for Turner syndrome. The different etiologies identified are 1) iatrogenic following chemotherapy and/or radiotherapy, 2) autoimmune, 3) viral, 4) genetic (RFSH, FOXL2, FRAXA, BMP15, GDF9, GALT, 17 hydroxylase...). Management of these patients includes hormone replacement therapy in order to avoid an increase in cardiovascular risk and osteoporosis related to hypoestrogenism. infertility is common, as only 3 to 10% of the patients will have natural conception. When fertility is desired, women with POF should be oriented towards oocyte donation centers. Research is currently performed in order to identify new genes involved in POF.

引用

页码：557 / 566

页数：10

共 83 条

[1]

PREGNANCY IN WOMEN WITH PREMATURE OVARIAN FAILURE USING TUBAL AND INTRAUTERINE TRANSFER OF CRYOPRESERVED ZYGOTES [J].