Global distribution and reduced penetrance: Lrrk2 R1441C in an Irish Parkinson's disease kindred

被引:12
作者
Gosal, David [1 ]
Lynch, Timothy
Ross, Owen A.
Haugarvoll, Kristoffer
Farrer, Matthew J.
Gibson, J. Mark
机构
[1] Mater Misericordiae Univ Hosp, Dept Neurol, Dublin 7, Ireland
[2] Univ Coll Dublin, Dublin 2, Ireland
[3] Mayo Clin Coll Med, Dept Neurosci, Jacksonville, FL USA
[4] Royal Victoria Hosp, Dept Neurol, Belfast BT12 6BA, Antrim, North Ireland
关键词
D O I
10.1002/mds.21200
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:291 / 292
页数:2
相关论文
共 7 条
  • [1] Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism:: Evidence of a common founder across European populations
    Kachergus, J
    Mata, IF
    Hulihan, M
    Taylor, JP
    Lincoln, S
    Aasly, J
    Gibson, JM
    Ross, OA
    Lynch, T
    Wiley, J
    Payami, H
    Nutt, J
    Maraganore, DM
    Czyzewski, K
    Styczynska, M
    Wszolek, ZK
    Farrer, MJ
    Toft, M
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (04) : 672 - 680
  • [2] Lrrk2 pathogenic substitutions in Parkinson's disease
    Mata, IF
    Kachergus, JM
    Taylor, JP
    Lincoln, S
    Aasly, J
    Lynch, T
    Hulihan, MM
    Cobb, SA
    Wu, RM
    Lu, CS
    Lahoz, C
    Wszolek, ZK
    Farrer, MJ
    [J]. NEUROGENETICS, 2005, 6 (04) : 171 - 177
  • [3] LRRK2 in Parkinson's disease: protein domains and functional insights
    Mata, Ignacio F.
    Wedemeyer, William J.
    Farrer, Matthew J.
    Taylor, Julie P.
    Gallo, Kathleen A.
    [J]. TRENDS IN NEUROSCIENCES, 2006, 29 (05) : 286 - 293
  • [4] Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
    Paisán-Ruíz, C
    Jain, S
    Evans, EW
    Gilks, WP
    Simón, J
    van der Brug, M
    de Munain, AL
    Aparicio, S
    Gil, AM
    Khan, N
    Johnson, J
    Martinez, JR
    Nicholl, D
    Carrera, IM
    Pena, AS
    de Silva, R
    Lees, A
    Martí-Massó, JF
    Pérez-Tur, J
    Wood, NW
    Singleton, AB
    [J]. NEURON, 2004, 44 (04) : 595 - 600
  • [5] Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease
    Tan, E. K.
    Skipper, Lisa
    Chua, Eva
    Wong, Meng-Cheong
    Pavanni, Ratnagopal
    Bonnard, Carine
    Kolatkar, Prasanna
    Liu, Jian-Jun
    [J]. MOVEMENT DISORDERS, 2006, 21 (07) : 997 - 1001
  • [6] A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations
    Zabetian, CP
    Samii, A
    Mosley, AD
    Roberts, JW
    Leis, BC
    Yearout, D
    Raskind, WH
    Griffith, A
    [J]. NEUROLOGY, 2005, 65 (05) : 741 - 744
  • [7] Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
    Zimprich, A
    Biskup, S
    Leitner, P
    Lichtner, P
    Farrer, M
    Lincoln, S
    Kachergus, J
    Hulihan, M
    Uitti, RJ
    Calne, DB
    Stoessl, AJ
    Pfeiffer, RF
    Patenge, N
    Carbajal, IC
    Vieregge, P
    Asmus, F
    Müller-Myhsok, B
    Dickson, DW
    Meitinger, T
    Strom, TM
    Wszolek, ZK
    Gasser, T
    [J]. NEURON, 2004, 44 (04) : 601 - 607