Drug targeting to the brain

被引：264

作者：

de Boer, A. G. ^{[1
]}

Gaillard, P. J. ^{[1
]}

机构：

[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Blood Brain Barrier Res Grp, Div Pharmacol, NL-2300 RA Leiden, Netherlands

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2007年 / 47卷

关键词：

brain drug targeting; local delivery; global delivery; viral delivery; nonviral delivery;

D O I：

10.1146/annurev.pharmtox.47.120505.105237

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore often not able to cross these barriers. As a result, various drug delivery and targeting strategies are currently being developed to enhance the transport and distribution of drugs into the brain. Here we discuss briefly the biology and physiology of the blood-brain barrier (BBB) and the blood-cerebro-spinal-fluid barrier (BCSFB), and, in more detail, the possibilities for delivering large-molecular-weight drugs by local and global delivery and by viral and receptor-mediated nonviral drug delivery to the (human) brain.

引用

页码：323 / 355

页数：33

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