New bromotyrosine alkaloids from the marine sponge Psammaplysilla purpurea

被引：54

作者：

Tilvi, S ^{[1
]}

Rodrigues, C ^{[1
]}

Naik, CG ^{[1
]}

Parameswaran, PS ^{[1
]}

Wahidhulla, S ^{[1
]}

机构：

[1] Natl Inst Oceanog, Panaji, Goa, India

来源：

TETRAHEDRON | 2004年 / 60卷 / 45期

关键词：

antimicrobial activity; bromotyrosine alkaloids; marine sponge; Psammaplysilla purpurea; purpurealidin;

D O I：

10.1016/j.tet.2004.09.009

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Seven new bromotyrosine alkaloids Purpurealidin A, B, C, D, F, G, H and the known compounds Purealidin Q, Purpurealidin E, 16-Debromoaplysamine-4 and Purpuramine I have been isolated from the marine sponge Psammaplysilla purpurea. Their structure was elucidated on the basis of detailed 1D, 2D NMR and MS spectroscopic data. Purpurealidin B, 16-Debromoaplysamine-4 and Purpuramine I exhibited in vitro antimicrobial activities against E. coli, S. aureus, and V. cholerae. In addition, Purpurealidin B and 16-Debromoaplysamine-4 were also active against Shigella flexineri and Salmonella typhi while Purealidin Q was bactericidal only against Salmonella typhi. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：10207 / 10215

页数：9

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