The nucleolus: the magician's hat for cell cycle tricks

被引：131

作者：

Visintin, R ^{[1
]}

Amon, A ^{[1
]}

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0955-0674(00)00102-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nucleolus, for decades considered a ribosome factory and site for ribosomal RNA synthesis and processing, has recently acquired new fame. Analyses of proteins important for cell-cycle regulation have shown that this organelle is used to sequester proteins, thereby inhibiting their activity.

引用

收藏

页码：372 / 377

页数：6

相关论文

共 57 条

[31] ONCOPROTEIN MDM2 CONCEALS THE ACTIVATION DOMAIN OF TUMOR SUPPRESSOR-P53 [J].

OLINER, JD ;

PIETENPOL, JA ;

THIAGALINGAM, S ;

GVURIS, J ;

KINZLER, KW ;

VOGELSTEIN, B .

NATURE, 1993, 362 (6423) :857-860

[32] The plurifunctional nucleolus [J].

Pederson, T .

NUCLEIC ACIDS RESEARCH, 1998, 26 (17) :3871-3876

[33] The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53 [J].

Pomerantz, J ;

Schreiber-Agus, N ;

Liegeois, NJ ;

Silverman, A ;

Alland, L ;

Chin, L ;

Potes, J ;

Chen, K ;

Orlow, I ;

Lee, HW ;

Cordon-Cardo, C ;

DePinho, RA .

CELL, 1998, 92 (06) :713-723

[34] Signaling to p53: Breaking the MDM2-p53 circuit [J].

Prives, C .

CELL, 1998, 95 (01) :5-8

[35] Meiotic chromosomes: it takes two to tango [J].

Roeder, GS .

GENES & DEVELOPMENT, 1997, 11 (20) :2600-2621

[36] Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein [J].

Roth, J ;

Dobbelstein, M ;

Freedman, DA ;

Shenk, T ;

Levine, AJ .

EMBO JOURNAL, 1998, 17 (02) :554-564

[37] Pch2 links chromatin silencing to meiotic checkpoint control [J].

San-Segundo, PA ;

Roeder, GS .

CELL, 1999, 97 (03) :313-324

[38] Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 [J].

Seol, JH ;

Feldman, RMR ;

Zachariae, W ;

Shevchenko, A ;

Correll, CC ;

Lyapina, S ;

Chi, Y ;

Galova, M ;

Claypool, J ;

Sandmeyer, S ;

Nasmyth, K ;

Shevchenko, A ;

Deshaies, RJ .

GENES & DEVELOPMENT, 1999, 13 (12) :1614-1626

[39] DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 [J].

Shieh, SY ;

Ikeda, M ;

Taya, Y ;

Prives, C .

CELL, 1997, 91 (03) :325-334

[40] Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex [J].

Shou, WY ;

Seol, JH ;

Shevchenko, A ;

Baskerville, C ;

Moazed, D ;

Chen, ZWS ;

Jang, J ;

Shevchenko, A ;

Charbonneau, H ;

Deshaies, RJ .

CELL, 1999, 97 (02) :233-244

← 1 2 3 4 5 6 →