The PPAR regulatory system in cardiac physiology and disease

被引：167

作者：

Finck, Brian N.

机构：

[1] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Cardiovasc Res Ctr, St Louis, MO 63110 USA

来源：

CARDIOVASCULAR RESEARCH | 2007年 / 73卷 / 02期

关键词：

lipid metabolism; energy metabolism; transgenic animal models; mitochondria; diabetes;

D O I：

10.1016/j.cardiores.2006.08.023

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial energy metabolism is an important determinant of cardiac structure and function. Modulating metabolism is therefore an attractive therapeutic avenue for the treatment of cardiac disease. The peroxisome proliferator-activated receptor family (PPAR alpha, beta/delta, gamma) of nuclear receptor transcription factors is an important regulator of cardiac metabolism and has been targeted for pharmacologic therapies designed to modulate metabolism. The PPARs control myocardial metabolism by transcriptionally regulating genes encoding enzymes involved in fatty acid and glucose utilization. The expression and activity of the PPARs and their coactivator protein PGC-1 alpha is dynamically regulated in several cardiomyopathic and metabolic diseases. This review will summarize these findings and other recent studies regarding the effects of experimental PPAR activation and deactivation and its potential impact on cardiomyopathic remodeling. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：269 / 277

页数：9

相关论文

共 117 条

[1] Effect of BM 17.0744, a PPARα ligand, on the metabolism of perfused hearts from control and diabetic mice [J].

Aasum, E ;

Cooper, M ;

Severson, DL ;

Larsen, TS .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2005, 83 (02) :183-190

[2] Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-α activator [J].

Aasum, E ;

Belke, DD ;

Severson, DL ;

Riemersma, RA ;

Cooper, M ;

Andreassen, M ;

Larsen, TS .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 283 (03) :H949-H957

[3] Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle [J].

Arany, Z ;

He, HM ;

Lin, JD ;

Hoyer, K ;

Handschin, C ;

Toka, O ;

Ahmad, F ;

Matsui, T ;

Chin, S ;

Wu, PH ;

Rybkin, II ;

Shelton, JM ;

Manieri, M ;

Cinti, S ;

Schoen, FJ ;

Bassel-Duby, R ;

Rosenzweig, A ;

Ingwall, JS ;

Spiegelman, BM .

CELL METABOLISM, 2005, 1 (04) :259-271

[4] Peroxisome proliferator-activated receptor γ plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo [J].

Asakawa, M ;

Takano, H ;

Nagai, T ;

Uozumi, H ;

Hasegawa, H ;

Kubota, N ;

Saito, T ;

Masuda, Y ;

Kadowaki, T ;

Komuro, I .

CIRCULATION, 2002, 105 (10) :1240-1246

[5] Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer [J].

Barak, Y ;

Liao, D ;

He, WM ;

Ong, ES ;

Nelson, MC ;

Olefsky, JM ;

Boland, R ;

Evans, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :303-308

[6] PPARγ is required for placental, cardiac, and adipose tissue development [J].

Barak, Y ;

Nelson, MC ;

Ong, ES ;

Jones, YZ ;

Ruiz-Lozano, P ;

Chien, KR ;

Koder, A ;

Evans, RM .

MOLECULAR CELL, 1999, 4 (04) :585-595

[7] Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth [J].

Barger, PM ;

Brandt, JM ;

Leone, TC ;

Weinheimer, CJ ;

Kelly, DP .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (12) :1723-1730

[8] p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α -: A potential role in the cardiac metabolic stress response [J].

Barger, PM ;

Browning, AC ;

Garner, AN ;

Kelly, DP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (48) :44495-44501

[9] PPAR signaling in the control of cardiac energy metabolism [J].

Barger, PM ;

Kelly, DP .

TRENDS IN CARDIOVASCULAR MEDICINE, 2000, 10 (06) :238-245

[10] Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice [J].

Belke, DD ;

Larsen, TS ;

Gibbs, EM ;

Severson, DL .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 279 (05) :E1104-E1113

← 1 2 3 4 5 6 7 8 9 10 →