Estimating the benefit of an HIV-1 vaccine that reduces viral load set point

被引:52
作者
Gupta, Swati B.
Jacobson, Lisa P.
Margolick, Joseph B.
Rinaldo, Charles R.
Phair, John P.
Jamieson, Beth D.
Mehrotra, Devan V.
Robertson, Michael N.
Straus, Walter L.
机构
[1] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA
[3] Northwestern Univ, Howard Brown Hlth Ctr, Chicago, IL 60611 USA
[4] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[5] David Geffen Sch Med, Los Angeles, CA USA
关键词
D O I
10.1086/510909
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vaccines designed to induce cell-mediated immune responses against human immunodeficiency virus (HIV)-1 are being developed. Such vaccines are unlikely to provide sterilizing immunity but may be associated with reduced viral set points after infection. We modeled the potential impact of a vaccine that reduces viral set point after infection, using natural history data from 311 HIV-1 seroconverters. Log-normal parametric regression models were used to estimate the log median time to events of interest. Relative times were estimated for those with viral load set points of 30,000 copies/mL (reference group) versus those with lower viral set points. The time to key clinical events in the course of HIV-1 disease progression was significantly extended for those with viral set points 0.5-1.25 log(10) copies/mL lower than the reference group. By quantifying the anticipated clinical benefits associated with a reduction in viral set point, these findings support the use of virologic end points in HIV-1 vaccine trials.
引用
收藏
页码:546 / 550
页数:5
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