Chk2 leaves the PML depot

被引：4

作者：

Venere, M ^{[1
]}

Mochan, TA ^{[1
]}

Halazonetis, TD ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

NATURE CELL BIOLOGY | 2002年 / 4卷 / 11期

关键词：

D O I：

10.1038/ncb1102-e255

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Chk2 checkpoint kinase is implicated in radiation-induced apoptosis. New findings suggest that radiation induces dissociation of Chk2 from the promyelocytic leukemia gene product (PML). Thus, PML nuclear bodies may function as regulated storage depots, releasing specific proteins in response to specific types of cellular stress.

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页码：E255 / E256

页数：2

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