Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists

被引:32
作者
Chenard, BL [1 ]
Menniti, FS [1 ]
Pagnozzi, MJ [1 ]
Shenk, KD [1 ]
Ewing, FE [1 ]
Welch, WM [1 ]
机构
[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA
关键词
D O I
10.1016/S0960-894X(00)00216-X
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Quinazolin-4-one derivatives of methaqualone substituted at C-2 define a new class of noncompetitive antagonists at AMPA receptors. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1203 / 1205
页数:3
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