Prospective study of renal insufficiency after bone marrow transplantation

被引:86
作者
Kist-van Holthe, JE
Goedvolk, CA
Brand, R
van Weel, MH
Bredius, RGM
van Oostayen, JA
Vossen, JMJJ
van der Heijden, BJ
机构
[1] Leiden Univ, Med Ctr, Dept Pediat, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Dept Med Stat, NL-2300 RA Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Radiol, NL-2300 RC Leiden, Netherlands
[4] Acad Med Ctr, NL-1100 DD Amsterdam, Netherlands
关键词
bone marrow transplantation; risk factor; acute renal insufficiency; chronic renal insufficiency;
D O I
10.1007/s00467-002-0989-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Since more and more children survive allogeneic bone marrow transplantation (BMT), knowledge of acute and late complications becomes increasingly important. Besides the major complications [(opportunistic) infections, veno-occlusive disease, graft versus host disease, and recurrence of primary disease], acute and chronic renal insufficiency are significant post-transplant complications that may contribute to transplant-related mortality. To elucidate risk factors for acute and chronic renal insufficiency post BMT, we performed a prospective study of all 66 children who received a BMT in a 2-year period at our institution; 21% had acute renal insufficiency post BMT. Risk factors for acute renal insufficiency were veno-occlusive disease, high cyclosporin serum levels' and foscarnet therapy. Of surviving patients, 11% developed chronic renal insufficiency 1 year post BMT. Acute renal insufficiency was the sole predictor of chronic renal insufficiency. In contrast to studies in adults, we did not find total body irradiation to be a risk factor for chronic renal insufficiency. Future long-term studies are needed to assess incidence and morbidity of chronic renal insufficiency in children following allogeneic BMT.
引用
收藏
页码:1032 / 1037
页数:6
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