2-alkyl-1-(2-aryl-1,1-difluoro-2-hydroxyethyl)benzimidazoles: potential angiotensin II receptor antagonists

被引：21

作者：

Yagupolskii, LM ^{[1
]}

Fedyuk, DV ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)00148-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Alkyl-1-(bromodifluoromethyl)benzimidazoles were synthesized and condensed with aromatic aldehydes to give 2-alkyl-1-(2-aryl-1, 1-difluoro-2-hydroxyethyl)-benzimidazoles. potential nonpeptide antagonist of the angiotensin II receptor with the -CF2CH(OH)-bridge between the heterocyclic nitrogen atom and the biphenyl moiety was synthesized. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2265 / 2267

页数：3

共 4 条

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