Resolution and biological activities of optical isomers of 1,4-diethyl-3,6-epidithiopiperazine-2,5-dione

被引：2

作者：

Hurne, AM ^{[1
]}

Simpson, J ^{[1
]}

Waring, P ^{[1
]}

Chai, CLL ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV,RES SCH CHEM,CANBERRA,ACT 0200,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(97)10052-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Epipolythiopiperazine-2,5-diones (ETPs) are an important class of biologically active fungal metabolites. We have successfully synthesised and resolved racemic 1,4-diethyl-3,6-epidithiopiperazine-2,5-dione using chiral HPLC. The biological activities of the enantiomers were investigated to determine the correlation between biological activity and chirality at the bridgehead carbons. (C) 1997 Elsevier Science Ltd.

引用

页码：2645 / 2650

页数：6

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