Analysis of T102C 5HT2A polymorphism in Brazilian psychiatric inpatients:: Relationship with suicidal Behavior

被引：18

作者：

Correa, H

De Marco, L

Boson, W

Viana, MM

Lima, VFS

Campi-Azevedo, AC

Noronha, JCM

Guatimosim, C

Romano-Silva, MA

机构：

[1] Univ Fed Minas Gerais, Dept Morphol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Hosp Clin, Serv Psiquiatria, Lab Farmacogenet, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Farmacol, Belo Horizonte, MG, Brazil

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2002年 / 22卷 / 5-6期

关键词：

suicide; serotonin; 5-HT2A polymorphism;

D O I：

10.1023/A:1021873411611

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. Central serotonergic dysfunction and genetic factors are associated with suicidal behavior in psychiatric patients. The goal of this study was to examine the association between the 5-HT2A gene polymorphism (102T/C) and suicide in a sample of Brazilian psychiatric inpatients. 2. We studied 225 subjects. Genotypic frequencies were obtained after DNA extraction and the region of 5-HT2A/T102C containing the polymorphic site amplified by the polymerase chain reaction and digested with the restriction enzyme HpaII. 3. No differences were found between patients with and without suicide attempt history. Patients with a history of severe suicide attempts also did not exhibit different genotypic frequencies when compared with patients without a suicide attempt history. 4. These results suggest that the 5HT(2A) gene polymorphism (102T/C) may not be involved in the genetic susceptibility to suicidal behavior.

引用

页码：813 / 817

页数：5

共 15 条

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