Alternative mechanisms for tiotropium

被引：95

作者：

Bateman, E. D. ^{[1
]}

Rennard, S. ^{[2
]}

Barnes, P. J. ^{[3
]}

Dicpinigaitis, P. V. ^{[4
]}

Gosens, R. ^{[5
]}

Gross, N. J. ^{[6
]}

Nadel, J. A. ^{[7
]}

Pfeifer, M. ^{[8
]}

Racke, K. ^{[9
]}

Rabe, K. F. ^{[10
]}

Rubin, B. K. ^{[11
]}

Welte, T. ^{[12
]}

Wessler, I. ^{[13
]}

机构：

[1] Univ Cape Town, Lung Inst, Dept Med, Div Pulm, ZA-7937 Cape Town, South Africa

[2] Univ Nebraska Med Ctr, Dept Internal Med, Pulm & Crit Care Med Sect, Omaha, NE USA

[3] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Thorac Med, London, England

[4] Montefiore Med Ctr, Einstein Div, Bronx, NY 10467 USA

[5] Univ Groningen, Dept Mol Pharmacol, Groningen, Netherlands

[6] Loyola Univ Chicago, Hines, IL USA

[7] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Pulm Med, San Francisco, CA 94143 USA

[8] Univ Regensburg, Regensburg, Germany

[9] Univ Bonn, Inst Pharmacol & Toxicol, D-5300 Bonn, Germany

[10] Leiden Univ, Med Ctr, Dept Pulmonol, Leiden, Netherlands

[11] Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Winston Salem, NC 27103 USA

[12] Hannover Med Sch, Abt Pneumol, D-30623 Hannover, Germany

[13] Johannes Gutenberg Univ Mainz, Univ Hosp, Inst Pathol, Mainz, Germany

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2009年 / 22卷 / 06期

关键词：

Tiotropium; COPD; Mechanisms; Inflammation; Remodelling; Mucus; Cough; BRONCHIAL EPITHELIAL-CELLS; POLYSPECIFIC CATION TRANSPORTERS; NONNEURONAL CHOLINERGIC SYSTEM; RECEPTORS MEDIATE STIMULATION; IPRATROPIUM BROMIDE; MUCOCILIARY CLEARANCE; ANTICHOLINERGIC BRONCHODILATOR; AIRWAY-OBSTRUCTION; INDUCED BRONCHOCONSTRICTION; COOPERATIVE REGULATION;

D O I：

10.1016/j.pupt.2009.06.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease. Although largely considered to be a long-acting bronchodilator, its demonstrated efficacy in reducing the frequency of exacerbations and preliminary evidence from early studies indicating that it might slow the rate of decline in lung function suggested mechanisms of action in addition to simple bronchodilation. This hypothesis was examined in the recently published UPLIFT study and, although spirometric and other clinical benefits of tiotropium treatment extended to four years, the rate of decline in lung function did not appear to be reduced by the addition of tiotropium in this study. This article summarizes data from a variety of investigations that provide insights into possible mechanisms to account for the effects of tiotropium. The report summarizes the discussion on basic and clinical research in this field. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：533 / 542

页数：10

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