The biological functions of C-reactive protein

We have obtained data from various investigations that firmly establishes an important host defense function for human C-reactive protein (CRP). In transgenic mice, the beneficial effect of CRP depends largely on its ability to recruit complement, Fcgamma receptors and the adaptive immune system; but this function is not limited to the blood-borne protein nor does it require a substantial rise in blood CRP levels. Moreover, in clinical studies, we have observed that differences in baseline levels of CRP among individuals correlate with a polymorphism in the CRP gene. The relevance of this finding is underlined by the observation that subtle elevation of blood CRP is associated with significantly increased risk of cardiac disease. (C) 2002 Elsevier Science Inc. All rights reserved.