O-protecting groups as long-range stereocontrolling elements in the addition of acetylides to 4-substituted quinolines

被引：18

作者：

Guanti, G ^{[1
]}

Perrozzi, S ^{[1
]}

Riva, R ^{[1
]}

机构：

[1] Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(02)00711-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Addition of magnesium acetylides in the presence of chloroformate esters to racemic differently O-protected 2-(4-quinolyl)propanols and to enantiopure 2-(4-quinolyl)-1,3-dialkoxypropanes, prepared by a chemoenzymatic route, gives almost exclusive regioselective attack at C-2, with stereoselectivities from moderate to good, depending mainly on the bulkiness of the O-protecting group present. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2703 / 2726

页数：24

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