In vivo induction of apoptosis correlating with reduced infectivity during baculovirus infection

被引：45

作者：

Clarke, TE ^{[1
]}

Clem, RJ ^{[1
]}

机构：

[1] Kansas State Univ, Div Biol, Mol Cellular & Dev Biol Program, Manhattan, KS 66506 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 03期

关键词：

D O I：

10.1128/JVI.77.3.2227-2232.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Spodoptera frugiperda caterpillars were infected with a mutant of Autographa californica M nucleopolyhedrovirus lacking the antiapoptotic p35 gene. Viral infectivity, replication, and spread were substantially reduced compared to that of a control revertant virus. Terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling confirmed that apoptosis occurred in mutant-infected caterpillars, thus directly correlating reduced infectivity and in vivo induction of apoptosis.

引用

页码：2227 / 2232

页数：6

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