Base excision repair in yeast and mammals

被引:231
作者
Memisoglu, A [1 ]
Samson, L [1 ]
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Canc Cell Biol, Boston, MA 02115 USA
关键词
base excision repair; yeast; mammals;
D O I
10.1016/S0027-5107(00)00039-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Base excision repair (BER), as initiated by at least seven different DNA glycosylases or by enzymes that cleave DNA at abasic sites, executes the repair of a wide variety of DNA damages. Many of these damages arise spontaneously because DNA interacts with the cellular milieu, and so BER profoundly influences spontaneous mutation rates. In addition, BER provides significant protection against the toxic and mutagenic effects of DNA damaging agents present in the external environment, and as such is likely to prevent the adverse health effects of such agents. BER pathways have been studied in a wide variety of organisms (including yeasts) and here we review how these varied studies have shaped our current view of human BER. (C) 2000 Published by Elsevier Science B.V.
引用
收藏
页码:39 / 51
页数:13
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