Thermochemical reaction of 7-azido-1-ethyl-6,8-difluoroquinolone-3-carboxylate with heterocyclic amines. An expeditious synthesis of novel fluoroquinolone derivatives

被引：19

作者：

Leyva, Socorro ^{[1
]}

Leyva, Elisa ^{[1
]}

机构：

[1] Univ Autonoma San Luis Potosi, Fac Ciencias Quim, Mexico City 78210, DF, Mexico

来源：

TETRAHEDRON | 2007年 / 63卷 / 09期

关键词：

fluoroquinolone; antibacterial; aryl azide; singlet nitrene;

D O I：

10.1016/j.tet.2006.11.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 7-hydrazino-1-ethyl-6,8-difluoroquinolone-3-carboxylate derivatives are obtained by thermochemical reaction of 7-azido-1-ethyl-6,8-difluoroquinolone-3-carboxylate with heterocyclic amines. These new fluoroquinolone carboxylates could be used as precursors in the preparation of novel fluoroquinolone carboxylic acids. These latter compounds are known to have biological activity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2093 / 2097

页数：5

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