XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis

被引：16

作者：

Cao, Y ^{[1
]}

Zhao, H ^{[1
]}

Grunz, H ^{[1
]}

机构：

[1] Univ Essen Gesamthsch, Dept Zoophysiol, D-45117 Essen, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 119卷 / 01期

关键词：

XETOR; ETO/MTG8; proneural genes; neurogenic genes; primary neurogenesis; Xenopus laevis;

D O I：

10.1016/S0925-4773(02)00285-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interaction between early proneural genes and lateral inhibition determines the number of primary neurons. The mechanism for regulating the size of the proneural domain, however, has not been clarified. We show here that inhibition of the function of XETOR in Xenopus, a homolog of human oncoprotein ETO/MTG8, leads to a neurogenic phenotype of expanded proneural domain without alteration in the density of primary neurons. This result suggests that XETOR is a prerequisite for regulating the size of the proneural domain. We further show that such a regulation is accomplished by establishing a, negative feedback loop between XETOR and proneural genes except Xngnr-1, as well as by antagonism between XETOR and lateral inhibition. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：35 / 44

页数：10

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