Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil

被引：30

作者：

de Medeiros, Luzidalva Barbosa

Lacerda, Heloisa Ramos

Salustiano Cavalcanti, Ana Maria

Pessoa Militao de Albuquerque, Maria de Fatima

机构：

[1] Univ Fed Pernambuco, Hosp Clin Pos Grad Med Trop, BR-50670420 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Dept Clin Med, BR-50670420 Recife, PE, Brazil

[3] Secretaria Estadual Saude Pernambuco, Cent Lab, Recife, PE, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2006年 / 101卷 / 08期

关键词：

human imunodeficiency virus type 1; primary resistance to drugs; genotyping; subtypes; Brazil;

D O I：

10.1590/S0074-02762006000800004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied Genotyping was performed using the ViroSeq (TM) Geno yping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%) Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.

引用

页码：845 / 849

页数：5

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